+10 m, p=0.005), improved New York Heart Association (NYHA) class by at least one class (68% vs. Changes in the background medical therapy were discouraged during the six-month period of randomized controlled study.ĭevice implantation was unsuccessful in 8% of patients, and was complicated by refractory hypotension, bradycardia, or asystole in four patients (two that died) and by perforation of the coronary sinus requiring pericardiocentesis in two patients.Ĭompared with placebo, CRT was associated with a significantly improved six-minute walk distance (+39 vs. Patients who had been prescribed beta-blockers were required to be on a stable regimen for three months. Concomitant Medications:Īll patients were required to be on stable medications for one month, including an angiotensin-converting enzyme (ACE) inhibitor or ACE inhibitor substitute. These patients were then followed up at nine months, and all patients continue to be followed at six-month intervals following the double-blind period of the controlled study. The electrophysiologist served as an unblinded third party, and the heart failure specialist, the managing physician, and the patient were kept blinded to study assignment during the six-month period of pivotal study.Ĭontrol arm patients could then go into the resynchronization mode. Following successful lead placement (93%), patients underwent a predischarge randomization to the control group (no CRT, n=225) or CRT group (n=228), then underwent a six-month period of double-blinded study with follow-up at one, three, and six months. Peak oxygen consumption time on a treadmill LV ejection fraction (LVEF) and end-diastolic dimension severity of mitral regurgitation duration of QRS interval and a clinical composite response, which assigns patients to one of three response groups: improved, worsened, or unchanged Drug/Procedures Used:įollowing baseline assessment, patients underwent implant attempt within one week. Minnesota Living With Heart Failure Questionnaire Quality of Life (QOL) Measure More than two infusions per week of positive inotrope Primary Endpoints:ġ. Ventricular tachycardia associated with reversible causesġ7. Life expectancy from noncardiac disease <6 monthsġ6. Chronic atrial arrhythmia within past monthġ4. Hepatic function >3 x upper limit of normalġ2. Existing pacing system or contraindications for standard cardiac pacingĩ. Existing implantable cardioverter defibrillator (ICD) or indications for an ICDĥ. Cerebrovascular accident or transient ischemic event within the past three monthsĤ. Unstable angina, acute myocardial infarction, coronary artery bypass graft, or percutaneous transluminal coronary angioplasty within the past three monthsģ. Six-minute walking distance of ≤450 m Exclusions:Ģ. LV end-diastolic dimension at least 55 mm (mean 69 mm)ĥ. LV systolic dysfunction with an LVEF ≤35%Ĥ. It should be noted that Timberlake and Chasez were the only two members of the group to pursue solo music careers after the disbandment.3. It's likely that this increased creative involvement is what Timberlake is referring to when he says that he felt he cared more about music than some of his bandmates who remained uninvolved in the writing or production process. While the songs on 'NSYNC's first two albums were written and produced for the group, Timberlake and fellow group member JC Chasez wrote and produced many of the tracks on Celebrity. It was in the production of that album that Timberlake was also starting to take a lot more control over his music. The stadium tour that Justin Timberlake is referring to is 'NSYNC's 2001 PopOdyssey tour, in promotion of the group's third and final album Celebrity. And I felt like I had other music I wanted to make and that I needed to follow my heart. I felt like I cared more about the music than some of the other people in the group. It started as a fun snowball fight that was becoming an avalanche. We were on a stadium tour, and I just felt like the whole thing was too big. Timberlake detailed the reasons he decided to move on from 'NSYNC back in 2002, saying that the group had simply gotten too big to the point where it became more stressful than enjoyable, and also that he was ready to get started on his solo career. Along with worldwide success comes a ton of pressure, Justin Timberlake pointed out in a new profile piece for The Hollywood Reporter.
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